Antimicrobial resistance (AMR) is one of the most pressing public health challenges worldwide. AMR occurs when antimicrobials, such as antibiotics, become ineffective against the microorganisms that cause disease. This ineffectiveness can lead to serious infections, increased mortality, and significant economic losses.

The Global Antibiotic Policy Initiative (GAPi) project aims to evaluate which decisions regarding antibiotic exposure targets and intervention implementation are optimal based on available data from the UK and Thailand. This collaborative project is led by St. George’s, University of London, in partnership with the University of Oxford, the Center for Global Development (CGD), the One Health Trust, and HITAP, with funding support from the Wellcome Trust.

In this project, national and global trends in antibiotic exposure will be collected across the quadripartite sectors (work stream 1). Model structures needed to capture the relevant health-economic consequences of intervention implementation will be developed (work stream 2). Current evidence about the parameters required to populate these models will be synthesised (work stream 3). Finally, exposure targets and the implementation of interventions aimed at reducing the AMR burden will be evaluated based on their net monetary benefits (work stream 4). The final GAPi model will involve a cost-effectiveness analysis, supplemented by macroeconomic and value of information techniques and will help assess when the interventions should be implemented. This model will be adapted for Thai setting and findings will be shared with regional collaborators.